GeneRulor Custom Probe Design

1. Service Introduction

The high-performance hybridization capture probe design service provided by GeneRulor Co., Ltd. integrates cutting-edge bioinformatics algorithms and a professional experimental validation platform to deliver precise and efficient probe solutions for targeted sequencing. Our probe design system accommodates projects ranging from single-gene to whole-exome scale, generating optimized probe sequences to ensure maximum coverage of target regions and minimal non-specific binding.

2. Technical Advantages

(1) Ultra-high specificity: Patented algorithms optimize probe sequences, significantly reducing non-specific hybridization rates.

(2) Comprehensive coverage: Accurate coverage of target regions with no blind spots, improving capture efficiency by 30%.

(3) Flexible customization: Supports diverse needs from single genes to whole exomes, with customization available for SNV, CNV, fusion gene detection and other special requirements.

(4) Cross-species compatibility: Supports probe design for human, mouse, rat and other model and non-model organisms.

(5) Difficult-region targeting: Innovative technologies address traditionally hard-to-capture regions such as extremely high/low GC content and repetitive sequences.

3. Design Process

Figure 1 Schematic diagram of the customized probe design service workflow.

4. Application Areas

(1) Clinical diagnosis: Precise diagnosis of genetic diseases and tumors, and guidance for targeted therapy.

(2) Drug development: Biomarker screening in targeted drug research and development.

(3) Basic research: In-depth sequencing analysis of specific gene families or pathways.

(4) Population studies: High-throughput sequencing of specific regions in large-scale samples.

5. Success Cases

The probe design service of GeneRulor Co.,Ltd. has been successfully applied in numerous research projects and clinical assay developments. It has helped customers achieve target region coverage of up to 99.8% and control sequencing depth variation within 20%, providing solid technical support for precision medicine research and clinical applications.

Whether you require standard panels for common diseases or highly customized solutions for special needs, GeneRulorCo., Ltd. is able to provide you with premium hybridization capture probe design services.