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Minicircle DNA
Minicircle DNA (mcDNA) is an advanced, non-viral, extrachromosomal vector engineered via site-specific recombination to retain only the essential eukaryotic expression cassette. This optimized, minimalist design intrinsically mitigates the significant immunogenicity, gene silencing, and strict regulatory risks associated with residual bacterial backbones in traditional plasmid vectors. To maximize the clinical potential of advanced gene and nucleic acid therapeutics, GeneRulor introduces the proprietary MiniPlasmid-Pro system. By deeply integrating an enhanced triplex DNA and streptavidin magnetic bead purification platform, our process eliminates structural impurities to achieve an unprecedented mcDNA purity of 99.97%. This breakthrough delivers a highly secure, efficient, and globally regulatory-compliant vector solution to seamlessly accelerate your clinical translation.

GeneRulor deeply cultivates the field of protein expression and purification, offering a comprehensive, multi-species platform tailored to diverse research and industrial scenarios. Our versatile infrastructure seamlessly integrates a highly efficient E. coli prokaryotic system for rapid, expedited turnarounds; a robust mammalian cell system—encompassing both transient transfection and stable cell line generation—to ensure precise folding and complex post-translational modifications (PTMs) for critical antibodies; and a scalable yeast system that flawlessly balances eukaryotic expression fidelity with operational simplicity. Leveraging mature technical expertise, our end-to-end services support the entire development lifecycle—from early-stage structural analysis and pilot studies to large-scale biomanufacturing—seamlessly accelerating your functional discoveries and therapeutic innovations.

Viral vectors are indispensable core tools driving advancements in gene therapy, cell therapy, and vaccine development. To address the industry's complex demands for vector engineering, scalable biomanufacturing, and rigorous quality control, GeneRulor provides an end-to-end CRO/CDMO platform. Specializing in lentiviral, adeno-associated virus (AAV), adenoviral, and novel virus-like particle (VLP) technologies, our comprehensive infrastructure encompasses seven major vector systems. From initial plasmid construction through to final GMP release, we deliver highly integrated, regulatory-compliant solutions to seamlessly accelerate your therapeutic pipeline from bench to clinic.

LsNP
CRISPR screening is a powerful high-throughput technology that leverages batch-designed sgRNAs and highly specific CRISPR editing to simultaneously knockout or regulate multiple genomic targets. To empower the rapid discovery of critical target genes, GeneRulor provides a comprehensive, one-stop CRISPR Screen solution backed by years of deep expertise in gene editing. Our end-to-end workflow seamlessly integrates custom sgRNA library design, oligo pool synthesis, plasmid library construction, lentiviral packaging, rigorous in vitro cell screening assays, and high-depth NGS bioinformatics analysis. This fully integrated platform delivers robust, highly reproducible data to seamlessly accelerate your target identification, mechanism-of-action studies, and broader functional genomics research.
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E-Mail：service@generulor.com
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