STAT6 Protein

Product Introduction

STAT6 (Signal Transducer and Activator of Transcription 6) is an important member of the STAT family (including STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6) and plays an irreplaceable regulatory role in the type II immune response of the body. The most notable feature of this protein is its specific responsiveness to IL-4 and IL-13 signals—STAT6 is the only protein in the STAT family that specifically responds to IL-4 and IL-13 signals, with irreplaceable function. STAT6 is activated through the classical JAK-STAT signaling pathway: when extracellular IL-4 or IL-13 bind to cell surface receptors, JAK kinases phosphorylate the receptor cytoplasmic tails, providing docking sites for STAT6. After recruitment, STAT6 itself is phosphorylated at tyrosine residue Y641 by JAK, then forms homodimers via its SH2 domain, translocates into the nucleus, and regulates the transcriptional expression of target genes. STAT6 primarily regulates the expression of Th2 immune response-related genes such as Arg-1, Mrc-1, Fizz-1, and Ym-1.